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Issue 32, 2016
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Site-selective incorporation and ligation of protein aldehydes

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Abstract

The incorporation of aldehyde handles into proteins, and subsequent chemical reactions thereof, is rapidly proving to be an effective way of generating homogeneous, covalently linked protein constructs that can display a vast array of functionality. In this review, we discuss methods for introducing aldehydes into target proteins, and summarise the ligation strategies for site-selective modification of proteins containing this class of functional handles.

Graphical abstract: Site-selective incorporation and ligation of protein aldehydes

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Publication details

The article was received on 11 Apr 2016, accepted on 30 Jun 2016 and first published on 30 Jun 2016


Article type: Review Article
DOI: 10.1039/C6OB00778C
Citation: Org. Biomol. Chem., 2016,14, 7622-7638
  • Open access: Creative Commons BY-NC license
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    Site-selective incorporation and ligation of protein aldehydes

    R. J. Spears and M. A. Fascione, Org. Biomol. Chem., 2016, 14, 7622
    DOI: 10.1039/C6OB00778C

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