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Issue 46, 2016
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F-THENA: a chiral derivatizing agent for the determination of the absolute configuration of secondary aromatic alcohols with a self-validating system

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Abstract

F-THENA is designed as an alternative fluorine-containing chiral derivatizing agent (CDA). The fluorine atom functions exclusively as a reporter which can directly sense an anisotropic effect from an aromatic substituent of a chiral alcohol. In combination with chemical shift differences from both 19F NMR and 1H NMR, the F-THENA method can successfully be used for determining the absolute configuration of chiral secondary aromatic alcohols with a self-validating system.

Graphical abstract: F-THENA: a chiral derivatizing agent for the determination of the absolute configuration of secondary aromatic alcohols with a self-validating system

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Publication details

The article was received on 17 Oct 2016, accepted on 31 Oct 2016 and first published on 01 Nov 2016


Article type: Paper
DOI: 10.1039/C6OB02255C
Citation: Org. Biomol. Chem., 2016,14, 11002-11012
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    F-THENA: a chiral derivatizing agent for the determination of the absolute configuration of secondary aromatic alcohols with a self-validating system

    K. Dolsophon, J. Soponpong, J. Kornsakulkarn, C. Thongpanchang, S. Prabpai, P. Kongsaeree and T. Thongpanchang, Org. Biomol. Chem., 2016, 14, 11002
    DOI: 10.1039/C6OB02255C

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