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Issue 48, 2016
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Macrolactam analogues of macrolide natural products

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Abstract

The chemical modification of macrolide natural products into aza- or lactam analogues is a strategy employed to improve their metabolic stability and biological activity. The methods for the synthesis of several lactam analogues of macrolide natural products are highlighted and aspects of their biological properties presented.

Graphical abstract: Macrolactam analogues of macrolide natural products

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Publication details

The article was received on 03 Oct 2016, accepted on 27 Oct 2016, published on 27 Oct 2016 and first published online on 27 Oct 2016


Article type: Review Article
DOI: 10.1039/C6OB02149B
Citation: Org. Biomol. Chem., 2016,14, 11301-11316
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    Macrolactam analogues of macrolide natural products

    H. M. Hügel, A. T. Smith and M. A. Rizzacasa, Org. Biomol. Chem., 2016, 14, 11301
    DOI: 10.1039/C6OB02149B

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