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Issue 48, 2016
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Flexible synthesis of cationic peptide–porphyrin derivatives for light-triggered drug delivery and photodynamic therapy

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Abstract

Efficient syntheses of cell-penetrating peptide–porphyrin conjugates are described using a variety of bioconjugation chemistries. This provides a flexible means to convert essentially hydrophobic tetrapyrolle photosensitisers into amphiphilic derivatives which are well-suited for use in light-triggered drug delivery by photochemical internalisation (PCI) and targeted photodynamic therapy (PDT).

Graphical abstract: Flexible synthesis of cationic peptide–porphyrin derivatives for light-triggered drug delivery and photodynamic therapy

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Publication details

The article was received on 30 Sep 2016, accepted on 14 Nov 2016 and first published on 14 Nov 2016


Article type: Paper
DOI: 10.1039/C6OB02135B
Citation: Org. Biomol. Chem., 2016,14, 11488-11501
  • Open access: Creative Commons BY license
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    Flexible synthesis of cationic peptide–porphyrin derivatives for light-triggered drug delivery and photodynamic therapy

    R. Dondi, E. Yaghini, K. M. Tewari, L. Wang, F. Giuntini, M. Loizidou, A. J. MacRobert and I. M. Eggleston, Org. Biomol. Chem., 2016, 14, 11488
    DOI: 10.1039/C6OB02135B

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