Jump to main content
Jump to site search

Issue 41, 2016
Previous Article Next Article

Metal-free one-pot α-carboxylation of primary alcohols

Author affiliations

Abstract

An efficient metal-free procedure for the formal α-carboxylation of primary alcohols has been developed. The method involves a one-pot oxidation/Passerini/hydrolysis sequence and provides access to α-hydroxy acids bearing a broad range of functional groups. A minor modification to the reaction conditions extends the range of accessible products to α-hydroxy esters.

Graphical abstract: Metal-free one-pot α-carboxylation of primary alcohols

Back to tab navigation

Supplementary files

Publication details

The article was received on 19 Aug 2016, accepted on 28 Sep 2016 and first published on 28 Sep 2016


Article type: Communication
DOI: 10.1039/C6OB01813K
Citation: Org. Biomol. Chem., 2016,14, 9716-9719
  •   Request permissions

    Metal-free one-pot α-carboxylation of primary alcohols

    G. van der Heijden, J. Kraakman, J. Biemolt, E. Ruijter and R. V. A. Orru, Org. Biomol. Chem., 2016, 14, 9716
    DOI: 10.1039/C6OB01813K

Search articles by author

Spotlight

Advertisements