Issue 39, 2016

Total synthesis of haliclamide

Abstract

A stereoselective approach for the synthesis of haliclamide 1, a marine natural product, has been developed. The notable features of our synthesis include MacMillan cross aldol, Mitsunobu inversion, Yamaguchi–Hirao alkylation, Steglich esterification and macrolactamization reactions and the Corey–Fuchs protocol as the key steps.

Graphical abstract: Total synthesis of haliclamide

Supplementary files

Article information

Article type
Paper
Submitted
15 Aug 2016
Accepted
02 Sep 2016
First published
02 Sep 2016

Org. Biomol. Chem., 2016,14, 9287-9293

Total synthesis of haliclamide

S. Gahalawat and S. K. Pandey, Org. Biomol. Chem., 2016, 14, 9287 DOI: 10.1039/C6OB01775D

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