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Issue 38, 2016
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Recent advances in the synthesis and application of fluorescent α-amino acids

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Abstract

Fluorescence spectroscopy has become a powerful technique for probing a range of complex biological processes including enzyme mechanisms and protein–protein interactions. While the application of this technique uses a number of strategies, many of these rely on the use of fluorescent α-amino acids. This review highlights the recent synthetic methods developed for the incorporation of highly conjugated chromophores into the side-chain of α-amino acids and the application of these compounds as probes for imaging in medicine and biology. In particular, the design and synthesis of α-amino acids bearing coumarin, flavone and polyaromatic derived chromophores is described.

Graphical abstract: Recent advances in the synthesis and application of fluorescent α-amino acids

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Publication details

The article was received on 08 Aug 2016, accepted on 30 Aug 2016 and first published on 30 Aug 2016


Article type: Review Article
DOI: 10.1039/C6OB01715K
Citation: Org. Biomol. Chem., 2016,14, 8911-8921
  • Open access: Creative Commons BY license
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    Recent advances in the synthesis and application of fluorescent α-amino acids

    A. H. Harkiss and A. Sutherland, Org. Biomol. Chem., 2016, 14, 8911
    DOI: 10.1039/C6OB01715K

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