Detection and quantification of ATP in human blood serum

Ali Akdeniz; Mehmet Gokhan Caglayan; Irina Polivina; Pavel Anzenbacher

doi:10.1039/C6OB01378C

Detection and quantification of ATP in human blood serum

Ali Akdeniz,^a Mehmet Gokhan Caglayan,^a^b Irina Polivina^a and Pavel Anzenbacher, Jr.*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, U.S.A
E-mail: pavel@bgsu.edu

^b Department of Analytical Chemistry, Faculty of Pharmacy, Ankara University, Ankara, Turkey

Abstract

Two fluorometric sensors based on the tri-serine tri-lactone scaffold and thiourea or sulfonamide moieties serving as hydrogen bond donors allowing for anion binding are described. The sensor utilizing thiourea as a recognition moiety shows fluorescence enhancement while the sensor with sulfonamide shows quenching upon addition of phosphates. Sensor arrays composed of two sensors are able to discriminate structurally similar organic phosphates in the presence of interferents in human blood serum. The quantitative analysis of ATP in human blood serum shows high accuracy (the root mean square error of prediction, 1.65%) without requiring any sample pretreatment.

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Publication details

The article was received on 25 Jun 2016, accepted on 06 Jul 2016 and first published on 06 Jul 2016

Article type: Communication

DOI: 10.1039/C6OB01378C

Citation: Org. Biomol. Chem., 2016,14, 7459-7462

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Detection and quantification of ATP in human blood serum

A. Akdeniz, M. G. Caglayan, I. Polivina and P. Anzenbacher, Org. Biomol. Chem., 2016, 14, 7459
DOI: 10.1039/C6OB01378C
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Organic & Biomolecular Chemistry

Detection and quantification of ATP in human blood serum

Abstract

Supplementary files

Publication details

Detection and quantification of ATP in human blood serum

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