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Issue 30, 2016
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Facile one-pot synthesis of unsymmetrical ureas, carbamates, and thiocarbamates from Cbz-protected amines

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Abstract

A novel one-pot synthesis of unsymmetrical ureas, carbamates and thiocarbamates from Cbz-protected amines has been developed. In the presence of 2-chloropyridine and trifluoromethanesulfonyl anhydride, isocyanates are generated in situ, which facilitate rapid reaction with amines, alcohols, and thiols to afford the corresponding ureas, carbamates and thiocarbamates in high yields.

Graphical abstract: Facile one-pot synthesis of unsymmetrical ureas, carbamates, and thiocarbamates from Cbz-protected amines

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Publication details

The article was received on 15 Jun 2016, accepted on 05 Jul 2016 and first published on 05 Jul 2016


Article type: Paper
DOI: 10.1039/C6OB01290F
Citation: Org. Biomol. Chem., 2016,14, 7345-7353
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    Facile one-pot synthesis of unsymmetrical ureas, carbamates, and thiocarbamates from Cbz-protected amines

    H. Kim and A. Lee, Org. Biomol. Chem., 2016, 14, 7345
    DOI: 10.1039/C6OB01290F

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