A prototype reversible polymersome-stabilized H2S photoejector operating under pseudophysiological conditions

Abstract

Persistent self-assembled polymersome capsules are shown to solubilise and stabilize a new hydrosulfide-containing (2), as well as hydroxylated (1), malachite green derivatives in their leuco-forms in aqueous buffer solution. Photoirradiation resulted in reversible hydroxide release/hydrogen sulfide generation. Notably, the efficient augmentation of H₂S concentration to physiologically-relevant levels is shown.