Issue 31, 2016

Recent advances in catalytic decarboxylative acylation reactions via a radical process

Abstract

The decarboxylative cross-coupling reactions of carboxylic acids have emerged as an efficient strategy for the C–C bond and C–X bond formations. In this field, the decarboxylative cross-coupling of α-keto acids has been developed as an attractive strategy to introduce a carbonyl group into versatile organic molecules. In particular, radical-mediated decarboxylative reactions have attracted much attention of chemists owing to their mild conditions, excellent functional group tolerance and high reactivity. In this review, we highlight the recent advances in the radical decarboxylative acylation reactions of α-keto acids.

Graphical abstract: Recent advances in catalytic decarboxylative acylation reactions via a radical process

Article information

Article type
Review Article
Submitted
21 May 2016
Accepted
27 Jun 2016
First published
27 Jun 2016

Org. Biomol. Chem., 2016,14, 7380-7391

Recent advances in catalytic decarboxylative acylation reactions via a radical process

L. Guo, H. Wang and X. Duan, Org. Biomol. Chem., 2016, 14, 7380 DOI: 10.1039/C6OB01113F

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