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Issue 24, 2016
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Palladium catalysed meta-C–H functionalization reactions

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The directing group assisted site selective C–H functionalization approach is having a continuous impact in the field of natural product synthesis, drug discovery and material sciences. While ortho-selective C–H functionalization has been studied extensively, meta-selective C–H functionalization has been less explored. Recent studies have highlighted the efficacy of palladium as a catalyst in activating the meta-C–H bond of arenes. Notably, the introduction of a novel palladium catalysed directing template based approach to activate the remote meta-position has created a revolutionary impact towards seeking a solution to this long standing challenge. In this review we summarize recent advances in palladium catalysed meta-C–H functionalization that have helped in creating a new outlook towards modern organic synthesis.

Graphical abstract: Palladium catalysed meta-C–H functionalization reactions

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Publication details

The article was received on 19 Feb 2016, accepted on 13 Apr 2016 and first published on 14 Apr 2016

Article type: Review Article
DOI: 10.1039/C6OB00395H
Citation: Org. Biomol. Chem., 2016,14, 5440-5453
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    Palladium catalysed meta-C–H functionalization reactions

    A. Dey, S. Agasti and D. Maiti, Org. Biomol. Chem., 2016, 14, 5440
    DOI: 10.1039/C6OB00395H

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