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Issue 24, 2016
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Selective chemical labeling of proteins

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Abstract

Over the years, there have been remarkable efforts in the development of selective protein labeling strategies. In this review, we deliver a comprehensive overview of the currently available bioorthogonal and chemoselective reactions. The ability to introduce bioorthogonal handles to proteins is essential to carry out bioorthogonal reactions for protein labeling in living systems. We therefore summarize the techniques that allow for site-specific “installation” of bioorthogonal handles into proteins. We also highlight the biological applications that have been achieved by selective chemical labeling of proteins.

Graphical abstract: Selective chemical labeling of proteins

  • This article is part of the themed collection: New Talent
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Publication details

The article was received on 15 Jan 2016, accepted on 23 Feb 2016 and first published on 23 Feb 2016


Article type: Review Article
DOI: 10.1039/C6OB00126B
Citation: Org. Biomol. Chem., 2016,14, 5417-5439
  • Open access: Creative Commons BY license
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    Selective chemical labeling of proteins

    X. Chen and Y. Wu, Org. Biomol. Chem., 2016, 14, 5417
    DOI: 10.1039/C6OB00126B

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