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Issue 24, 2016
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Phage-displayed macrocyclic glycopeptide libraries

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Abstract

In this report, we describe an efficient way to generate libraries of macrocyclic glycopeptides in one step by reacting phage-displayed libraries of peptides with dichloro-oxime derivatives. We showed that the reactions do not interfere with the ability of phage to replicate in bacteria. The reactions are site-selective for phage-displayed peptides and they do not modify any other proteins of phage. The technology described in this report will be instrumental for genetic selection of macrocyclic glycopeptides for diverse glycan-binding proteins.

Graphical abstract: Phage-displayed macrocyclic glycopeptide libraries

  • This article is part of the themed collection: New Talent
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Publication details

The article was received on 24 Dec 2015, accepted on 02 Feb 2016 and first published on 04 Feb 2016


Article type: Communication
DOI: 10.1039/C5OB02646F
Citation: Org. Biomol. Chem., 2016,14, 5539-5545
  • Open access: Creative Commons BY license
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    Phage-displayed macrocyclic glycopeptide libraries

    S. Ng and R. Derda, Org. Biomol. Chem., 2016, 14, 5539
    DOI: 10.1039/C5OB02646F

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