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Issue 2, 2016
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A protocol for amide bond formation with electron deficient amines and sterically hindered substrates

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Abstract

A protocol for amide coupling by in situ formation of acyl fluorides and reaction with amines at elevated temperature has been developed and found to be efficient for coupling of sterically hindered substrates and electron deficient amines where standard methods failed.

Graphical abstract: A protocol for amide bond formation with electron deficient amines and sterically hindered substrates

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Publication details

The article was received on 14 Oct 2015, accepted on 05 Nov 2015, published on 05 Nov 2015 and first published online on 05 Nov 2015


Article type: Communication
DOI: 10.1039/C5OB02129D
Citation: Org. Biomol. Chem., 2016,14, 430-433
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    A protocol for amide bond formation with electron deficient amines and sterically hindered substrates

    M. E. Due-Hansen, S. K. Pandey, E. Christiansen, R. Andersen, S. V. F. Hansen and T. Ulven, Org. Biomol. Chem., 2016, 14, 430
    DOI: 10.1039/C5OB02129D

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