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Issue 17, 2016
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Internalized compartments encapsulated nanogels for targeted drug delivery

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Abstract

Drug delivery systems inspired by natural particulates hold great promise for targeted cancer therapy. An endosome formed by internalization of plasma membrane has a massive amount of membrane proteins and receptors on the surface, which is able to specifically target the homotypic cells. Herein, we describe a simple method to fabricate an internalized compartments encapsulated nanogel with endosome membrane components (EM-NG) from source cancer cells. Following intracellular uptake of methacrylated hyaluronic acid (m-HA) adsorbed SiO2/Fe3O4 nanoparticles encapsulating a crosslinker and a photoinitiator, EM-NG was readily prepared through in situ crosslinking initiated under UV irradiation after internalization. The resulting nanogels loaded with doxorubicin (DOX) displayed enhanced internalization efficiency to the source cells through a specific homotypic affinity in vitro. However, when treated with the non-source cells, the EM-NGs exhibited insignificant difference in therapeutic efficiency compared to a bare HA nanogel with DOX. This study illustrates the potential of utilizing an internalized compartments encapsulated formulation for targeted cancer therapy, and offers guidelines for developing a natural particulate-inspired drug delivery system.

Graphical abstract: Internalized compartments encapsulated nanogels for targeted drug delivery

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Publication details

The article was received on 15 Dec 2015, accepted on 25 Mar 2016 and first published on 14 Apr 2016


Article type: Paper
DOI: 10.1039/C5NR08895J
Citation: Nanoscale, 2016,8, 9178-9184
  • Open access: Creative Commons BY-NC license
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    Internalized compartments encapsulated nanogels for targeted drug delivery

    J. Yu, Y. Zhang, W. Sun, C. Wang, D. Ranson, Y. Ye, Y. Weng and Z. Gu, Nanoscale, 2016, 8, 9178
    DOI: 10.1039/C5NR08895J

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