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Issue 10, 2016
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DNA origami based Au–Ag-core–shell nanoparticle dimers with single-molecule SERS sensitivity

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Abstract

DNA origami nanostructures are a versatile tool to arrange metal nanostructures and other chemical entities with nanometer precision. In this way gold nanoparticle dimers with defined distance can be constructed, which can be exploited as novel substrates for surface enhanced Raman scattering (SERS). We have optimized the size, composition and arrangement of Au/Ag nanoparticles to create intense SERS hot spots, with Raman enhancement up to 1010, which is sufficient to detect single molecules by Raman scattering. This is demonstrated using single dye molecules (TAMRA and Cy3) placed into the center of the nanoparticle dimers. In conjunction with the DNA origami nanostructures novel SERS substrates are created, which can in the future be applied to the SERS analysis of more complex biomolecular targets, whose position and conformation within the SERS hot spot can be precisely controlled.

Graphical abstract: DNA origami based Au–Ag-core–shell nanoparticle dimers with single-molecule SERS sensitivity

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Publication details

The article was received on 06 Dec 2015, accepted on 11 Feb 2016 and first published on 11 Feb 2016


Article type: Paper
DOI: 10.1039/C5NR08674D
Citation: Nanoscale, 2016,8, 5612-5620
  • Open access: Creative Commons BY license
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    DNA origami based Au–Ag-core–shell nanoparticle dimers with single-molecule SERS sensitivity

    J. Prinz, C. Heck, L. Ellerik, V. Merk and I. Bald, Nanoscale, 2016, 8, 5612
    DOI: 10.1039/C5NR08674D

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