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Issue 25, 2016
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Porphyrin-loaded nanoparticles for cancer theranostics

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Abstract

Porphyrins have been used as pioneering theranostic agents not only for the photodynamic therapy, sonodynamic therapy and radiotherapy of cancer, but also for diagnostic fluorescence imaging, magnetic resonance imaging and photoacoustic imaging. A variety of porphyrins have been developed but very few of them have actually been employed in clinical trials due to their poor selectivity to tumorous tissue and high accumulation rates in the skin. In addition, most porphyrin molecules are hydrophobic and form aggregates in aqueous media. Nevertheless, the use of nanoparticles as porphyrin carriers shows great promise to overcome these shortcomings. Encapsulating or attaching porphyrins to nanoparticles makes them more suitable for tissue delivery because we can create materials with a conveniently specific tissue lifetime, specific targeting, immune tolerance, and hydrophilicity as well as other characteristics through rational design. In addition, various functional components (e.g. for targeting, imaging or therapeutic functions) can be easily introduced into a single nanoparticle platform for cancer theranostics. This review presents the current state of knowledge on porphyrin-loaded nanoparticles for the interwined imaging and therapy of cancer. The future trends and limitations of prophyrin-loaded nanoparticles are also outlined.

Graphical abstract: Porphyrin-loaded nanoparticles for cancer theranostics

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Publication details

The article was received on 08 Nov 2015, accepted on 13 Dec 2015 and first published on 16 Dec 2015


Article type: Review Article
DOI: 10.1039/C5NR07849K
Citation: Nanoscale, 2016,8, 12394-12405
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    Porphyrin-loaded nanoparticles for cancer theranostics

    Y. Zhou, X. Liang and Z. Dai, Nanoscale, 2016, 8, 12394
    DOI: 10.1039/C5NR07849K

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