Jump to main content
Jump to site search

Issue 7, 2016
Previous Article Next Article

Hyperbranched polymer mediated size-controlled synthesis of gadolinium phosphate nanoparticles: colloidal properties and particle size-dependence on MRI relaxivity

Author affiliations

Abstract

Hyperbranched polymers based on the poly(amidoamine), HyPAM, were used to synthesize gadolinium phosphate nanowires under mild conditions. Control of the average particle size was obtained by adjusting polymer concentration. Proton relaxivity measurements reveal an optimum particle size, reaching relaxivity values as high as 55 ± 9 mM−1 s−1 for r1 and 67 ± 11 mM−1 s−1 for r2. The colloidal stability of these hybrid systems were optimized through the use of functionalized core–shell polymers containing PEG segments and C18-PEG segments, structures which also offer the possibility of imparting additional function into the polymer-particle hybrids.

Graphical abstract: Hyperbranched polymer mediated size-controlled synthesis of gadolinium phosphate nanoparticles: colloidal properties and particle size-dependence on MRI relaxivity

Back to tab navigation

Supplementary files

Publication details

The article was received on 28 Jul 2015, accepted on 25 Jan 2016 and first published on 26 Jan 2016


Article type: Paper
DOI: 10.1039/C5NR05064B
Citation: Nanoscale, 2016,8, 4252-4259
  •   Request permissions

    Hyperbranched polymer mediated size-controlled synthesis of gadolinium phosphate nanoparticles: colloidal properties and particle size-dependence on MRI relaxivity

    C. Frangville, M. Gallois, Y. Li, H. H. Nguyen, N. Lauth-de Viguerie, D. R. Talham, C. Mingotaud and J. Marty, Nanoscale, 2016, 8, 4252
    DOI: 10.1039/C5NR05064B

Search articles by author

Spotlight

Advertisements