Jump to main content
Jump to site search

Issue 15, 2016
Previous Article Next Article

Applicability of avidin protein coated mesoporous silica nanoparticles as drug carriers in the lung

Author affiliations

Abstract

Mesoporous silica nanoparticles (MSNs) exhibit unique drug delivery properties and are thus considered as promising candidates for next generation nano-medicines. In particular, inhalation into the lungs represents a direct, non-invasive delivery route for treating lung disease. To assess MSN biocompatibility in the lung, we investigated the bioresponse of avidin-coated MSNs (MSN-AVI), as well as aminated (uncoated) MSNs, after direct application into the lungs of mice. We quantified MSN distribution, clearance rate, cell-specific uptake, and inflammatory responses to MSNs within one week after instillation. We show that amine-functionalized (MSN-NH2) particles are not taken up by lung epithelial cells, but induced a prolonged inflammatory response in the lung and macrophage cell death. In contrast, MSN-AVI co-localized with alveolar epithelial type 1 and type 2 cells in the lung in the absence of sustained inflammatory responses or cell death, and showed preferential epithelial cell uptake in in vitro co-cultures. Further, MSN-AVI particles demonstrated uniform particle distribution in mouse lungs and slow clearance rates. Thus, we provide evidence that avidin functionalized MSNs (MSN-AVI) have the potential to serve as versatile biocompatible drug carriers for lung-specific drug delivery.

Graphical abstract: Applicability of avidin protein coated mesoporous silica nanoparticles as drug carriers in the lung

Back to tab navigation

Supplementary files

Publication details

The article was received on 21 Jun 2015, accepted on 07 Mar 2016 and first published on 10 Mar 2016


Article type: Paper
DOI: 10.1039/C5NR04119H
Citation: Nanoscale, 2016,8, 8058-8069
  • Open access: Creative Commons BY license
  •   Request permissions

    Applicability of avidin protein coated mesoporous silica nanoparticles as drug carriers in the lung

    S. H. van Rijt, D. A. Bölükbas, C. Argyo, K. Wipplinger, M. Naureen, S. Datz, O. Eickelberg, S. Meiners, T. Bein, O. Schmid and T. Stoeger, Nanoscale, 2016, 8, 8058
    DOI: 10.1039/C5NR04119H

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements