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Issue 8, 2016
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Computational genomic identification and functional reconstitution of plant natural product biosynthetic pathways

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Abstract

Covering: 2003 to 2016

The last decade has seen the first major discoveries regarding the genomic basis of plant natural product biosynthetic pathways. Four key computationally driven strategies have been developed to identify such pathways, which make use of physical clustering, co-expression, evolutionary co-occurrence and epigenomic co-regulation of the genes involved in producing a plant natural product. Here, we discuss how these approaches can be used for the discovery of plant biosynthetic pathways encoded by both chromosomally clustered and non-clustered genes. Additionally, we will discuss opportunities to prioritize plant gene clusters for experimental characterization, and end with a forward-looking perspective on how synthetic biology technologies will allow effective functional reconstitution of candidate pathways using a variety of genetic systems.

Graphical abstract: Computational genomic identification and functional reconstitution of plant natural product biosynthetic pathways

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Publication details

The article was received on 15 Mar 2016 and first published on 20 Jun 2016


Article type: Review Article
DOI: 10.1039/C6NP00035E
Citation: Nat. Prod. Rep., 2016,33, 951-962
  • Open access: Creative Commons BY license
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    Computational genomic identification and functional reconstitution of plant natural product biosynthetic pathways

    M. H. Medema and A. Osbourn, Nat. Prod. Rep., 2016, 33, 951
    DOI: 10.1039/C6NP00035E

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