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Issue 4, 2016
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Neurite outgrowth enhancement by jiadifenolide: possible targets

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Abstract

Covering: 1860-2016

A mechanistic link may exist between convulsant plant substances typified by picrotoxinin, and ‘neurotrophic’ sesquiterpenes like jiadifenolide. Picrotoxinin elicits convulsion by anion blockade of the Cys-loop family of neurotransmitter-gated ion channels. These same receptors mediate neuronal development and neurite outgrowth prior to synapse formation. Due to its structural homology with picrotoxin and anisatin, it is possible that jiadifenolide enhances NGF-stimulated neurite outgrowth by modulation of the Cys-loop family of receptors.

Graphical abstract: Neurite outgrowth enhancement by jiadifenolide: possible targets

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Publication details

The article was received on 23 Dec 2015 and first published on 18 Feb 2016


Article type: Viewpoint
DOI: 10.1039/C5NP00160A
Citation: Nat. Prod. Rep., 2016,33, 535-539
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    Neurite outgrowth enhancement by jiadifenolide: possible targets

    R. A. Shenvi, Nat. Prod. Rep., 2016, 33, 535
    DOI: 10.1039/C5NP00160A

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