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Issue 5, 2016
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Discoveries, target identifications, and biological applications of natural products that inhibit splicing factor 3B subunit 1

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Abstract

Covering: 1992 to 2015

The natural products FR901464, pladienolide, and herboxidiene were discovered as activators of reporter gene systems. Unexpectedly, these compounds target neither transcription nor translation; rather, they target splicing factor 3B subunit 1 of the spliceosome, causing changes in splicing patterns. All of them showed anticancer activity in a low nanomolar range. Since their discovery, these molecules have been used in a variety of biological applications.

Graphical abstract: Discoveries, target identifications, and biological applications of natural products that inhibit splicing factor 3B subunit 1

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Publication details

The article was received on 07 Sep 2015 and first published on 26 Jan 2016


Article type: Highlight
DOI: 10.1039/C5NP00110B
Citation: Nat. Prod. Rep., 2016,33, 637-647
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    Discoveries, target identifications, and biological applications of natural products that inhibit splicing factor 3B subunit 1

    D. Pham and K. Koide, Nat. Prod. Rep., 2016, 33, 637
    DOI: 10.1039/C5NP00110B

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