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Issue 7, 2016
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Deciphering the CHEF-PET-ESIPT liaison mechanism in a Zn2+ chemosensor and its applications in cell imaging study

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Abstract

Proper fusion of fluorescence mechanisms in a single fluorophore unit is highly desirable to obtain better sensitivity, as well as selectivity towards a particular metal ion. In this regard, a Zn2+ chemosensor exhibiting strong fluorescence through synergistic CHEF-PET-ESIPT fluorescence mechanism has not received substantial deployment. This type of chemosensor provides an ample avenue to detect metal ions with a large stokes shift and are useful in living cell imaging study. Herein, we report an unparalleled Zn2+ chemosensor (L) based on these three types of fluorescence mechanisms by condensing 2,6-diformyl-4-methylphenol and 2-hydrazinyl-4,6-dimethylpyrimidine. All the three types of mechanism were experimentally verified by UV-Vis, fluorescence and time resolved photoluminescence (TRPL) spectroscopic evaluation. The sensor L and Zn2+ formed a 1 : 1 ratio complex demonstrating a high binding constant value (Ka = 4.812 × 105 M−1) and L showed clear discrimination from the Cd2+ ion. The limit of detection (LOD) and limit of quantification (LOQ) were calculated to be 9.727 × 10−7 (M) and 3.24 × 10−6 (M), respectively. We have also shown that cell imaging can be performed using L without many cytotoxicity concerns.

Graphical abstract: Deciphering the CHEF-PET-ESIPT liaison mechanism in a Zn2+ chemosensor and its applications in cell imaging study

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Publication details

The article was received on 07 Feb 2016, accepted on 08 Jun 2016 and first published on 08 Jun 2016


Article type: Paper
DOI: 10.1039/C6NJ00234J
Citation: New J. Chem., 2016,40, 5976-5984
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    Deciphering the CHEF-PET-ESIPT liaison mechanism in a Zn2+ chemosensor and its applications in cell imaging study

    A. Jana, B. Das, S. K. Mandal, S. Mabhai, A. R. Khuda-Bukhsh and S. Dey, New J. Chem., 2016, 40, 5976
    DOI: 10.1039/C6NJ00234J

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