Tricarbonylrhenium(I) complexes with 2-acetylpyridine-derived hydrazones are cytotoxic to NCI-H460 human large cell lung cancer

Camila Vargas Garcia; Gabrieli Lessa Parrilha; Bernardo Lages Rodrigues; Sarah Fernandes Teixeira; Ricardo Alexandre de Azevedo; Adilson Kleber Ferreira; Heloisa Beraldo

doi:10.1039/C6NJ00050A

Tricarbonylrhenium(I) complexes with 2-acetylpyridine-derived hydrazones are cytotoxic to NCI-H460 human large cell lung cancer

Camila Vargas Garcia,^a Gabrieli Lessa Parrilha,^a Bernardo Lages Rodrigues,^a Sarah Fernandes Teixeira,^b Ricardo Alexandre de Azevedo,^b Adilson Kleber Ferreira^b and Heloisa Beraldo*^a

Author affiliations

* Corresponding authors

^a Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
E-mail: hberaldo@ufmg.br

^b Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil

Abstract

Complexes [ReCl(CO)₃(H2AcPh)] (1), [ReCl(CO)₃(H2AcpClPh)]·0.5C₇H₈ (2) and [ReCl(CO)₃(H2AcpNO₂Ph)]·0.5C₇H₈ (3) were obtained with 2-acetylpyridine-phenylhydrazone (H2AcPh) and its para-chlorophenylhydrazone (H2AcpClPh) and para-nitrophenylhydrazone (H2AcpNO₂Ph) analogues. Coordination to tricarbonylrhenium(I) resulted in a higher antiproliferative activity against NCI-H460 human large cell lung cancer. Complexes (2) and (3) induced apoptosis on NCI-H460 cells. Complex (2) induced mitochondrial damage while treatment with 3 showed a later response, suggesting that probably the same effect would be observed at higher concentrations or longer treatments. Both complexes (2) and (3) showed a high antioxidant activity, 2 being more potent in reducing intracellular reactive oxygen species (ROS) production.

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Publication details

The article was received on 08 Feb 2016, accepted on 15 Jun 2016 and first published on 15 Jun 2016

Article type: Paper

DOI: 10.1039/C6NJ00050A

Citation: New J. Chem., 2016,40, 7379-7387

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Tricarbonylrhenium(I) complexes with 2-acetylpyridine-derived hydrazones are cytotoxic to NCI-H460 human large cell lung cancer

C. V. Garcia, G. L. Parrilha, B. L. Rodrigues, S. F. Teixeira, R. A. de Azevedo, A. K. Ferreira and H. Beraldo, New J. Chem., 2016, 40, 7379
DOI: 10.1039/C6NJ00050A
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New Journal of Chemistry

Tricarbonylrhenium(I) complexes with 2-acetylpyridine-derived hydrazones are cytotoxic to NCI-H460 human large cell lung cancer

Abstract

Supplementary files

Publication details

Tricarbonylrhenium(I) complexes with 2-acetylpyridine-derived hydrazones are cytotoxic to NCI-H460 human large cell lung cancer

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