Issue 3, 2016
From the journal:

New Journal of Chemistry

Design of an amphiphilic porphyrin exhibiting high in vitro photocytotoxicity†

Derya Topkaya,*ab   Dominique Lafont,c   Florent Poyer,de   Guillaume Garcia,de   Florian Albrieux,f   Philippe Maillard,de   Yann Bretonnièreg  and  Fabienne Dumoulin*a  

* Corresponding authors

a Gebze Technical University, Department of Chemistry, P. O. box 141, 41400 Gebze Kocaeli, Turkey
E-mail: fdumoulin@gtu.edu.tr

b University of Dokuz Eylül, Department of Chemistry, Faculty of Science, 35160 Tınaztepe Izmir, Turkey
E-mail: derya.topkaya@deu.edu.tr

c Institut de Chimie et Biochimie Moléculaires et Supramoléculaires, CO2-Glyco, UMR 5246, CNRS, Université Claude Bernard Lyon 1, Université de Lyon, 43 Boulevard du 11 Novembre 1918, F-6922 Villeurbanne, France

d Institut Curie, Research Center, Chemistry, Modelisation and Imaging for Biology (CMIB) Bât 110-112, Centre Universitaire, F-91405 Orsay, France

e CNRS UMR 9187 – INSERM U 1196, Paris-Saclay Université Paris Sud 11, Bât 110-112, Centre Universitaire, Rue Henri Becquerel F-91405 Orsay Cedex, France

f Centre Commun de Spectrométrie de Masse UMR 5246, CNRS-Claude Bernard Lyon 1, Université de Lyon, Bâtiment Curien, 43, bd du 11 Novembre, 69622 Villeurbanne Cedex, France

g ENS Lyon, Université de Lyon, Laboratoire de Chimie de l’ENS Lyon, UMR 5182 CNRS-ENS Lyon, 46 allée d’Italie, 69364 Lyon, France

Abstract

A porphyrin monosubstituted by three triethyleneglycol chains grafted on a pentaerythritol skeleton was designed to display an optimized amphiphilicity for an enhanced cellular uptake and thus to exert enhanced photocytotoxicity. This porphyrin proved to be an excellent photosensitiser with submicromolar IC50.

Graphical abstract: Design of an amphiphilic porphyrin exhibiting high in vitro photocytotoxicity

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Article information

DOI
https://doi.org/10.1039/C5NJ02716K
Article type
Paper
Submitted
04 Oct 2015
Accepted
03 Dec 2015
First published
07 Dec 2015

New J. Chem., 2016,40, 2044-2050

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Design of an amphiphilic porphyrin exhibiting high in vitro photocytotoxicity

D. Topkaya, D. Lafont, F. Poyer, G. Garcia, F. Albrieux, P. Maillard, Y. Bretonnière and F. Dumoulin, New J. Chem., 2016, 40, 2044 DOI: 10.1039/C5NJ02716K

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