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Issue 3, 2016
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Design of an amphiphilic porphyrin exhibiting high in vitro photocytotoxicity

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Abstract

A porphyrin monosubstituted by three triethyleneglycol chains grafted on a pentaerythritol skeleton was designed to display an optimized amphiphilicity for an enhanced cellular uptake and thus to exert enhanced photocytotoxicity. This porphyrin proved to be an excellent photosensitiser with submicromolar IC50.

Graphical abstract: Design of an amphiphilic porphyrin exhibiting high in vitro photocytotoxicity

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Publication details

The article was received on 04 Oct 2015, accepted on 03 Dec 2015 and first published on 07 Dec 2015


Article type: Paper
DOI: 10.1039/C5NJ02716K
Citation: New J. Chem., 2016,40, 2044-2050
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    Design of an amphiphilic porphyrin exhibiting high in vitro photocytotoxicity

    D. Topkaya, D. Lafont, F. Poyer, G. Garcia, F. Albrieux, P. Maillard, Y. Bretonnière and F. Dumoulin, New J. Chem., 2016, 40, 2044
    DOI: 10.1039/C5NJ02716K

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