A colorimetric and fluorometric dual-modal DNA logic gate based on the response of a cyanine dye supramolecule to G-quadruplexes

Abstract

A colorimetric and fluorometric dual-modal DNA logic gate has been constructed, which is based on the response of a cyanine dye supramolecule to K⁺–Pb²⁺-switched G-quadruplexes. Only when the input is K⁺, the output is 1, which made the system an INHIBIT logic gate. The gate operation constructed here is label-free, and is of simple design and low-cost, showing great promise for practical onsite applications.