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Issue 3, 2016
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Design and functionalization of responsive hydrogels for photonic crystal biosensors

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Abstract

Photonic crystals embedded in analyte responsive hydrogels provide a powerful platform for biosensing and have benefitted from recent advances in polymer synthesis and functionalization, nanofabrication, and optical characterization. In this review, state-of-the-art techniques for the fabrication and functionalization of photonic crystal hydrogels are presented, along with a fundamental description of how such materials transduce detection of a target analyte into a simple optical readout. Specific biosensing applications using photonic crystal hydrogels are highlighted, including for the detection of DNA hybridization and single-site DNA modifications, enzyme activity, and small molecule metabolites. Moreover, perspectives on using molecular-level interactions to design and engineer more sensitive or more selective biosensors, as well as future directions in this expanding field, are discussed.

Graphical abstract: Design and functionalization of responsive hydrogels for photonic crystal biosensors

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Publication details

The article was received on 31 Mar 2016, accepted on 25 Apr 2016 and first published on 10 May 2016


Article type: Review Article
DOI: 10.1039/C6ME00031B
Citation: Mol. Syst. Des. Eng., 2016,1, 225-241
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    Design and functionalization of responsive hydrogels for photonic crystal biosensors

    S. Jung, J. L. Kaar and M. P. Stoykovich, Mol. Syst. Des. Eng., 2016, 1, 225
    DOI: 10.1039/C6ME00031B

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