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Issue 8, 2016
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Design, synthesis and evaluation of novel 19F magnetic resonance sensitive protein tyrosine phosphatase inhibitors

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Abstract

Fluorine is a highly attractive element for both medicinal chemistry and imaging technologies. To facilitate protein tyrosine phosphatase (PTP)-targeted drug discovery and imaging-guided PTP research on fluorine, several highly potent and 19F MR sensitive PTP inhibitors were discovered through a structure-based focused library strategy.

Graphical abstract: Design, synthesis and evaluation of novel 19F magnetic resonance sensitive protein tyrosine phosphatase inhibitors

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Publication details

The article was received on 21 May 2016, accepted on 17 Jun 2016 and first published on 20 Jun 2016


Article type: Research Article
DOI: 10.1039/C6MD00277C
Citation: Med. Chem. Commun., 2016,7, 1672-1680
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    Design, synthesis and evaluation of novel 19F magnetic resonance sensitive protein tyrosine phosphatase inhibitors

    Y. Li, G. Xia, Q. Guo, L. Wu, S. Chen, Z. Yang, W. Wang, Z. Zhang, X. Zhou and Z. Jiang, Med. Chem. Commun., 2016, 7, 1672
    DOI: 10.1039/C6MD00277C

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