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Issue 9, 2016
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Human lysosomal acid lipase inhibitor lalistat impairs Mycobacterium tuberculosis growth by targeting bacterial hydrolases

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Abstract

Lalistat inhibits growth of Mycobacterium tuberculosis in bacterial culture as well as in infected macrophages. Target identification by quantitative proteomics revealed a cluster of 20 hydrolytic proteins including members of the lipase family. Lipases are essential for M. tuberculosis fatty acid production and energy storage thus representing promising antibiotic targets.

Graphical abstract: Human lysosomal acid lipase inhibitor lalistat impairs Mycobacterium tuberculosis growth by targeting bacterial hydrolases

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Publication details

The article was received on 26 Apr 2016, accepted on 12 Jul 2016 and first published on 21 Jul 2016


Article type: Research Article
DOI: 10.1039/C6MD00231E
Citation: Med. Chem. Commun., 2016,7, 1797-1801
  • Open access: Creative Commons BY license
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    Human lysosomal acid lipase inhibitor lalistat impairs Mycobacterium tuberculosis growth by targeting bacterial hydrolases

    J. Lehmann, J. Vomacka, K. Esser, M. Nodwell, K. Kolbe, P. Rämer, U. Protzer, N. Reiling and S. A. Sieber, Med. Chem. Commun., 2016, 7, 1797
    DOI: 10.1039/C6MD00231E

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