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Issue 2, 2016
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Silver(I) complexes with quinazoline and phthalazine: synthesis, structural characterization and evaluation of biological activities

Nada D. Savić,a  Biljana Đ. Glišić,*a  Hubert Wadepohl,b  Aleksandar Pavic,c  Lidija Senerovic,c  Jasmina Nikodinovic-Runicc  and  Miloš I. Djurana 
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* Corresponding authors

a Department of Chemistry, Faculty of Science, University of Kragujevac, R. Domanovića 12, PO Box 60, 34000 Kragujevac, Serbia
E-mail: bglisic@kg.ac.rs

b Anorganisch-Chemisches Institut, University of Heidelberg, Im Neuenheimer Feld 270, 69120 Heidelberg, Germany

c Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11000 Belgrade, Serbia

Abstract

New silver(I) complexes with quinazoline (qz) and phthalazine (phtz), [Ag(NO3)(qz)]n (1) and {[Ag(CH3CN)]2(μ-phtz)2}[BF4]2 (2), have been synthesized and structurally characterized by using different spectroscopic and single-crystal X-ray diffraction techniques. The obtained results revealed that the reaction of AgNO3 with qz at room temperature in a 2 : 1 molar ratio led to the formation of the polynuclear complex 1. However, the reaction of AgBF4 with phtz under the same experimental conditions resulted in the formation of the dinuclear complex 2. The solution behaviour and air/light stability of these silver(I) complexes have been investigated. The complexes 1 and 2, along with the silver(I) salts used for their synthesis, were evaluated by in vitro antimicrobial studies against a panel of microbial strains that lead to many skin and soft tissue, respiratory, wound, and nosocomial infections. The obtained results indicate that all tested silver(I) compounds have good antibacterial activity with MIC values in the range from 1.5 to 15.6 μg mL−1 against the investigated strains. On the other hand, their antifungal activity against Candida albicans was moderate. In order to determine the therapeutic potential of 1 and 2, their antiproliferative effect on the normal human lung fibroblast cell line MRC5, hemolytic effect on red blood cells and embryotoxicity on zebrafish (Danio rerio) have also been evaluated.

Graphical abstract: Silver(i) complexes with quinazoline and phthalazine: synthesis, structural characterization and evaluation of biological activities

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Publication details

The article was received on 02 Nov 2015, accepted on 20 Nov 2015 and first published on 25 Nov 2015


Article type: Research Article
DOI: 10.1039/C5MD00494B
Author version available: Download Author version (PDF)
Citation: Med. Chem. Commun., 2016,7, 282-291
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    Silver(I) complexes with quinazoline and phthalazine: synthesis, structural characterization and evaluation of biological activities

    N. D. Savić, B. Đ. Glišić, H. Wadepohl, A. Pavic, L. Senerovic, J. Nikodinovic-Runic and M. I. Djuran, Med. Chem. Commun., 2016, 7, 282
    DOI: 10.1039/C5MD00494B

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