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Issue 4, 2016
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The ring residue proline 8 is crucial for the thermal stability of the lasso peptide caulosegnin II

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Abstract

Lasso peptides are fascinating natural products with a unique structural fold that can exhibit tremendous thermal stability. Here, we investigate factors responsible for the thermal stability of caulosegnin II. By employing X-ray crystallography, mutational analysis and molecular dynamics simulations, the ring residue proline 8 was proven to be crucial for thermal stability.

Graphical abstract: The ring residue proline 8 is crucial for the thermal stability of the lasso peptide caulosegnin II

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Publication details

The article was received on 01 Feb 2016, accepted on 05 Feb 2016 and first published on 05 Feb 2016


Article type: Communication
DOI: 10.1039/C6MB00081A
Citation: Mol. BioSyst., 2016,12, 1106-1109
  • Open access: Creative Commons BY-NC license
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    The ring residue proline 8 is crucial for the thermal stability of the lasso peptide caulosegnin II

    J. D. Hegemann, C. D. Fage, S. Zhu, K. Harms, F. S. Di Leva, E. Novellino, L. Marinelli and M. A. Marahiel, Mol. BioSyst., 2016, 12, 1106
    DOI: 10.1039/C6MB00081A

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