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Issue 7, 2016
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Stabilization of epigenetic states of CpG islands by local cooperation

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Abstract

DNA methylation of CpG sites is an important epigenetic mark in mammals. Active promoters are often associated with unmethylated CpG sites, whereas methylated CpG sites correlate with silenced promoters. Methylation of CpG sites must be generally described as a dynamical process that is mediated by methylation enzymes, such as DNMT1 and DNMT3a/b. However, there are several models of how CpG sites can be protected from methylation and thereby remain unmethylated. In this paper we examine the combination of both: the positive feedbacks of DNA methylation and a short range counterpart which in turn protects—and thereby maintains—the unmethylated state. The emergent dynamics is provided by collaborative, re-enforcing feedbacks in favor of methylated CpG islands and cooperative protection of one CpG site by another in favor of unmethylated CpG sites. Our results suggest that this synthesis of mechanisms provides equally robust maintenance of both the unmethylated and methylated states of CpG islands.

Graphical abstract: Stabilization of epigenetic states of CpG islands by local cooperation

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Publication details

The article was received on 19 Jan 2016, accepted on 17 Feb 2016 and first published on 22 Feb 2016


Article type: Paper
DOI: 10.1039/C6MB00044D
Citation: Mol. BioSyst., 2016,12, 2142-2146
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    Stabilization of epigenetic states of CpG islands by local cooperation

    G. Sormani, J. O. Haerter, C. Lövkvist and K. Sneppen, Mol. BioSyst., 2016, 12, 2142
    DOI: 10.1039/C6MB00044D

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