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Issue 2, 2016
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The differential expression of mRNAs and long noncoding RNAs between ectopic and eutopic endometria provides new insights into adenomyosis

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Abstract

Adenomyosis, defined as ectopic endometrial tissue within the myometrium, can often be misdiagnosed as multiple uterine leiomyomata or endometrial thickening. We therefore performed a combined mRNA and long noncoding (lnc)RNA microarray and bioinformatic analysis of eutopic and ectopic endometria in women with adenomyosis to better understand its pathogenesis and help in the development of a semi-invasive diagnostic test. A total of 586 mRNAs were increased and 305 mRNAs decreased in the ectopic endometrium of adenomyosis compared with the eutopic endometrium, while 388 lncRNA transcripts were up-regulated and 188 down-regulated in ectopic compared with paired eutopic endometrial tissue. Bioinformatic analysis suggested a series of metabolic and molecular abnormalities in adenomyosis, which have many similarities with endometriosis. Furthermore, our study constitutes the first known report of lncRNA expression patterns in human adenomyosis ectopic and eutopic endometrial tissue.

Graphical abstract: The differential expression of mRNAs and long noncoding RNAs between ectopic and eutopic endometria provides new insights into adenomyosis

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Publication details

The article was received on 30 Oct 2015, accepted on 20 Nov 2015 and first published on 10 Dec 2015


Article type: Paper
DOI: 10.1039/C5MB00733J
Citation: Mol. BioSyst., 2016,12, 362-370
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    The differential expression of mRNAs and long noncoding RNAs between ectopic and eutopic endometria provides new insights into adenomyosis

    C. Zhou, T. Zhang, F. Liu, J. Zhou, X. Ni, R. Huo and Z. Shi, Mol. BioSyst., 2016, 12, 362
    DOI: 10.1039/C5MB00733J

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