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Issue 3, 2016
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A quinazoline-based HDAC inhibitor affects gene expression pathways involved in cholesterol biosynthesis and mevalonate in prostate cancer cells

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Abstract

Chronic inflammation can lead to the development of cancers and resolution of inflammation is an ongoing challenge. Inflammation can result from dysregulation of the epigenome and a number of compounds that modify the epigenome are in clinical use. In this study the anti-inflammatory and anti-cancer effects of a quinazoline epigenetic-modulator compound were determined in prostate cancer cell lines using a non-hypothesis driven transcriptomics strategy utilising the Affymetrix PrimeView® Human Gene Expression microarray. GATHER and IPA software were used to analyse the data and to provide information on significantly modified biological processes, pathways and networks. A number of genes were differentially expressed in both PC3 and DU145 prostate cancer cell lines. The top canonical pathways that frequently arose across both cell lines at a number of time points included cholesterol biosynthesis and metabolism, and the mevalonate pathway. Targeting of sterol and mevalonate pathways may be a powerful anticancer approach.

Graphical abstract: A quinazoline-based HDAC inhibitor affects gene expression pathways involved in cholesterol biosynthesis and mevalonate in prostate cancer cells

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Publication details

The article was received on 17 Aug 2015, accepted on 16 Dec 2015 and first published on 06 Jan 2016


Article type: Paper
DOI: 10.1039/C5MB00554J
Citation: Mol. BioSyst., 2016,12, 839-849
  • Open access: Creative Commons BY license
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    A quinazoline-based HDAC inhibitor affects gene expression pathways involved in cholesterol biosynthesis and mevalonate in prostate cancer cells

    Z. Lin, K. S. Bishop, H. Sutherland, G. Marlow, P. Murray, W. A. Denny and L. R. Ferguson, Mol. BioSyst., 2016, 12, 839
    DOI: 10.1039/C5MB00554J

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