Jump to main content
Jump to site search

Issue 23, 2016
Previous Article Next Article

An inkjet printed, roll-coated digital microfluidic device for inexpensive, miniaturized diagnostic assays

Author affiliations

Abstract

The diagnosis of infectious disease is typically carried out at the point-of-care (POC) using the lateral flow assay (LFA). While cost-effective and portable, LFAs often lack the clinical sensitivity and specificity required for accurate diagnoses. In response to this challenge, we introduce a new digital microfluidic (DMF) platform fabricated using a custom inkjet printing and roll-coating process that is scalable to mass production. The performance of the new devices is on par with that of traditional DMF devices fabricated in a cleanroom, with a materials cost for the new devices of only US $0.63 per device. To evaluate the usefulness of the new platform, we performed a 13-step rubella virus (RV) IgG immunoassay on the inkjet printed, roll-coated devices, which yielded a limit of detection of 0.02 IU mL−1, well below the diagnostic cut-off of 10 IU mL−1 for RV infection and immunity. We propose that this represents a breakthrough for DMF, lowering the costs to a level such that the new platforms will be an attractive alternative to LFAs for the diagnosis of infectious disease at the POC.

Graphical abstract: An inkjet printed, roll-coated digital microfluidic device for inexpensive, miniaturized diagnostic assays

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 24 Aug 2016, accepted on 21 Oct 2016 and first published on 01 Nov 2016


Article type: Paper
DOI: 10.1039/C6LC01064D
Citation: Lab Chip, 2016,16, 4560-4568
  •   Request permissions

    An inkjet printed, roll-coated digital microfluidic device for inexpensive, miniaturized diagnostic assays

    C. Dixon, A. H. C. Ng, R. Fobel, M. B. Miltenburg and A. R. Wheeler, Lab Chip, 2016, 16, 4560
    DOI: 10.1039/C6LC01064D

Search articles by author