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Issue 18, 2016
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High-throughput acoustic separation of platelets from whole blood

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Abstract

Platelets contain growth factors which are important in biomedical and clinical applications. In this work, we present an acoustic separation device for high-throughput, non-invasive platelet isolation. In particular, we separated platelets from whole blood at a 10 mL min−1 throughput, which is three orders of magnitude greater than that of existing acoustic-based platelet separation techniques. Without sample dilution, we observed more than 80% RBC/WBC removal and platelet recovery. High throughput, high separation efficiency, and biocompatibility make this device useful for many clinical applications.

Graphical abstract: High-throughput acoustic separation of platelets from whole blood

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Publication details

The article was received on 25 May 2016, accepted on 22 Jul 2016 and first published on 01 Aug 2016


Article type: Paper
DOI: 10.1039/C6LC00682E
Author version available: Download Author version (PDF)
Citation: Lab Chip, 2016,16, 3466-3472
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    High-throughput acoustic separation of platelets from whole blood

    Y. Chen, M. Wu, L. Ren, J. Liu, P. H. Whitley, L. Wang and T. J. Huang, Lab Chip, 2016, 16, 3466
    DOI: 10.1039/C6LC00682E

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