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Issue 13, 2016
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Turning the corner in fertility: high DNA integrity of boundary-following sperm

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Abstract

We present a passive microfluidic sperm selection strategy that collects motile sperm based on their preference to follow boundaries and turn corners. Clinical assessment of selected human sperm from the device revealed a strong correlation between high DNA integrity and the tendency for sperm to follow boundaries. Human sperm with preference to follow boundaries on the left- or right-hand sides have higher (>51%) DNA integrity than straight swimmers and significantly higher (>67%) DNA integrity than sperm in raw semen. Boundary following behaviour offers a strategy to selecting sperm with the highest DNA integrity to improve the success rate of assisted reproduction.

Graphical abstract: Turning the corner in fertility: high DNA integrity of boundary-following sperm

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Publication details

The article was received on 12 Apr 2016, accepted on 23 May 2016 and first published on 23 May 2016


Article type: Communication
DOI: 10.1039/C6LC00490C
Citation: Lab Chip, 2016,16, 2418-2422
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    Turning the corner in fertility: high DNA integrity of boundary-following sperm

    L. Eamer, M. Vollmer, R. Nosrati, M. C. San Gabriel, K. Zeidan, A. Zini and D. Sinton, Lab Chip, 2016, 16, 2418
    DOI: 10.1039/C6LC00490C

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