Jump to main content
Jump to site search

Issue 4, 2016
Previous Article Next Article

Synthetic biology approaches in cancer immunotherapy, genetic network engineering, and genome editing

Author affiliations

Abstract

Investigations into cells and their contents have provided evolving insight into the emergence of complex biological behaviors. Capitalizing on this knowledge, synthetic biology seeks to manipulate the cellular machinery towards novel purposes, extending discoveries from basic science to new applications. While these developments have demonstrated the potential of building with biological parts, the complexity of cells can pose numerous challenges. In this review, we will highlight the broad and vital role that the synthetic biology approach has played in applying fundamental biological discoveries in receptors, genetic circuits, and genome-editing systems towards translation in the fields of immunotherapy, biosensors, disease models and gene therapy. These examples are evidence of the strength of synthetic approaches, while also illustrating considerations that must be addressed when developing systems around living cells.

Graphical abstract: Synthetic biology approaches in cancer immunotherapy, genetic network engineering, and genome editing

Back to tab navigation

Publication details

The article was received on 24 Dec 2015, accepted on 31 Mar 2016 and first published on 04 Apr 2016


Article type: Review Article
DOI: 10.1039/C5IB00325C
Citation: Integr. Biol., 2016,8, 504-517
  •   Request permissions

    Synthetic biology approaches in cancer immunotherapy, genetic network engineering, and genome editing

    D. Chakravarti, J. H. Cho, B. H. Weinberg, N. M. Wong and W. W. Wong, Integr. Biol., 2016, 8, 504
    DOI: 10.1039/C5IB00325C

Search articles by author

Spotlight

Advertisements