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Issue 4, 2016
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Genetically modified bacteriophages

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Phages or bacteriophages, viruses that infect and replicate inside bacteria, are the most abundant microorganisms on earth. The realization that antibiotic resistance poses a substantial risk to the world's health and global economy is revitalizing phage therapy as a potential solution. The increasing ease by which phage genomes can be modified, owing to the influx of new technologies, has led to an expansion of their natural capabilities, and a reduced dependence on phage isolation from environmental sources. This review will discuss the way synthetic biology has accelerated the construction of genetically modified phages and will describe the wide range of their applications. It will further provide insight into the societal and economic benefits that derive from the use of recombinant phages in various sectors, from health to biodetection, biocontrol and the food industry.

Graphical abstract: Genetically modified bacteriophages

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The article was received on 25 Oct 2015, accepted on 14 Feb 2016 and first published on 15 Feb 2016

Article type: Review Article
DOI: 10.1039/C5IB00267B
Citation: Integr. Biol., 2016,8, 465-474
  • Open access: Creative Commons BY license
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    Genetically modified bacteriophages

    A. P. Sagona, A. M. Grigonyte, P. R. MacDonald and A. Jaramillo, Integr. Biol., 2016, 8, 465
    DOI: 10.1039/C5IB00267B

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