Issue 3, 2017

An efficient approach to chloro(organophosphine) gold(i) complexes for the synthesis of auranofin

Abstract

A practical and efficient synthesis of chloro(organophosphine) gold(I) complexes is reported. Employment of 4,4′-dihydroxydiphenyl sulfide as a safe and non-irritating reductant is highlighted for the generation of Au(I)–S intermediates, which could be trapped by mono- and bidentate phosphine ligands to provide organophosphine gold(I) complexes. The utility of the present method is further demonstrated by the synthesis of the antiarthritic drug auranofin.

Graphical abstract: An efficient approach to chloro(organophosphine) gold(i) complexes for the synthesis of auranofin

Supplementary files

Article information

Article type
Communication
Submitted
20 Oct 2016
Accepted
05 Dec 2016
First published
06 Dec 2016

Green Chem., 2017,19, 634-637

An efficient approach to chloro(organophosphine) gold(I) complexes for the synthesis of auranofin

J. Wang, X. Mi, J. Wang and Y. Yang, Green Chem., 2017, 19, 634 DOI: 10.1039/C6GC02908F

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