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Issue 17, 2016
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Rapid, metal-free and aqueous synthesis of imidazo[1,2-a]pyridine under ambient conditions

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Abstract

A novel, rapid and efficient route to imidazo[1,2-a]pyridines under ambient, aqueous and metal-free conditions is reported. The NaOH-promoted cycloisomerisations of N-propargylpyridiniums give quantitative yield in a few minutes (10 g scale). A comparison of common green metrics to current routes showed clear improvements, with at least a one order of magnitude increase in space-time-yield.

Graphical abstract: Rapid, metal-free and aqueous synthesis of imidazo[1,2-a]pyridine under ambient conditions

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Publication details

The article was received on 13 Jun 2016, accepted on 14 Jul 2016 and first published on 14 Jul 2016


Article type: Communication
DOI: 10.1039/C6GC01601D
Citation: Green Chem., 2016,18, 4623-4627
  • Open access: Creative Commons BY license
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    Rapid, metal-free and aqueous synthesis of imidazo[1,2-a]pyridine under ambient conditions

    M. R. Chapman, M. H. T. Kwan, G. E. King, B. A. Kyffin, A. J. Blacker, C. E. Willans and B. N. Nguyen, Green Chem., 2016, 18, 4623
    DOI: 10.1039/C6GC01601D

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