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Issue 18, 2016
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A high-yielding method for the preparation of isoxazolopyridin-3-amine derivatives

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Abstract

A highly efficient and green method has been developed for the rapid preparation of highly functionalized isoxazolopyridin-3-amine derivatives in excellent yields. This process has a broad substrate scope, is operationally simple, and generally requires no chromatographic purification. In addition, the process is scalable and significantly greener than current alternatives with a PMI of 18 and water as the reaction solvent.

Graphical abstract: A high-yielding method for the preparation of isoxazolopyridin-3-amine derivatives

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Publication details

The article was received on 20 Apr 2016, accepted on 31 May 2016 and first published on 31 May 2016


Article type: Paper
DOI: 10.1039/C6GC01125J
Citation: Green Chem., 2016,18, 4941-4946
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    A high-yielding method for the preparation of isoxazolopyridin-3-amine derivatives

    W. Yu, P. G. Bulger and K. M. Maloney, Green Chem., 2016, 18, 4941
    DOI: 10.1039/C6GC01125J

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