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Issue 9, 2016
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Cajanus cajan – a source of PPARγ activators leading to anti-inflammatory and cytotoxic effects

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Abstract

Cajanus cajan is an important legume crop in the human diet in many parts of the world. Due to its pharmacological properties, C. cajan is, moreover, used in traditional medicine for treating skin diseases, diabetes, inflammatory disorders and various other dysfunctions. In this study, we focused on the role of peroxisome proliferator-activated receptor gamma (PPARγ) as a potential therapeutic target of Cajanus cajan and its main compounds for the treatment of cancer, inflammation and inflammation-related disorders. The anti-inflammatory potential of C. cajan and its bioactive compounds and their cytotoxicity on the human cervical adenocarcinoma cell line HeLa, the human colorectal adenocarcinoma cell line CaCo-2 and the human breast adenocarcinoma cell line MCF-7 were elucidated. C. cajan and its compounds exerted significant anti-inflammatory activity on lipopolysaccharide-stimulated macrophages, showed good cytotoxic effects on the 3 different cancer cell lines and proved PPARγ activity in vitro. The main active compounds were orientin, pinostrobin and vitexin. Cajaninstilbene acid and pinosylvin monomethylether were identified as novel PPARγ activators. Based on these data, C. cajan provides excellent beneficial medicinal attributes and may be used as a potential food or a pharmaceutical supplement.

Graphical abstract: Cajanus cajan – a source of PPARγ activators leading to anti-inflammatory and cytotoxic effects

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Publication details

The article was received on 10 May 2016, accepted on 14 Aug 2016 and first published on 06 Sep 2016


Article type: Paper
DOI: 10.1039/C6FO00689B
Citation: Food Funct., 2016,7, 3798-3806
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    Cajanus cajan – a source of PPARγ activators leading to anti-inflammatory and cytotoxic effects

    R. Schuster, W. Holzer, H. Doerfler, W. Weckwerth, H. Viernstein, S. Okonogi and M. Mueller, Food Funct., 2016, 7, 3798
    DOI: 10.1039/C6FO00689B

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