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Issue 2, 2016
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Keto analogue and amino acid supplementation and its effects on ammonemia and performance under thermoneutral conditions

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Abstract

Alterations of cerebral function, fatigue and disturbance in cognitive-motor performance can be caused by hyperammonemia and/or hot environmental conditions during exercise. Exercise-induced hyperammonemia can be reduced through supplementation with either amino acids or combined keto analogues and amino acids (KAAA) to improve exercise tolerance. In the present study, we evaluated KAAA supplementation on ammonia metabolism and cognitive-motor performance after high-intensity exercise under a low heat stress environment. Sixteen male cyclists received a ketogenic diet for 2 d and were divided into two groups, KAAA (KEx) or placebo (CEx) supplementation. The athletes performed a 2 h cycling session followed by a maximum test (MAX), and blood samples were obtained at rest and during exercise. Cognitive-motor tasks were performed before and after the protocol, and the exhaustion time was used to evaluate physical performance. The hydration status was also evaluated. The CEx group showed a significant increase (∼70%) in ammonia concentration at MAX, which did not change in the KEx group. The non-supplemented group showed a significant increase in uremia. Both the groups had a significant increase in blood urate concentrations at 120 min, and an early significant increase from 120 min was observed in the CEx group. There was no change in the glucose concentrations of the two groups. A significant increase in lactate was observed at the MAX moment in both groups. There was no significant difference in the exhaustion times between the groups. No changes were observed in the cognitive-motor tasks after the protocol. We suggest that KAAA supplementation decreases ammonia concentration during high-intensity exercise but does not affect physical or cognitive-motor performances under a low heat stress environment.

Graphical abstract: Keto analogue and amino acid supplementation and its effects on ammonemia and performance under thermoneutral conditions

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Publication details

The article was received on 02 Sep 2015, accepted on 16 Nov 2015 and first published on 08 Dec 2015


Article type: Paper
DOI: 10.1039/C5FO01054C
Author version available: Download Author version (PDF)
Citation: Food Funct., 2016,7, 872-880
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    Keto analogue and amino acid supplementation and its effects on ammonemia and performance under thermoneutral conditions

    S. R. A. E. S. Camerino, R. C. P. Lima, T. C. L. França, E. D. A. Herculano, D. S. A. Rodrigues, M. G. D. S. Gouveia, L. C. Cameron and E. S. Prado, Food Funct., 2016, 7, 872
    DOI: 10.1039/C5FO01054C

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