Issue 45, 2016

CO-releasing molecule (CORM) conjugate systems

Abstract

The development of CORMs (CO-releasing molecules) as a prodrug for CO administration in living organisms has attracted significant attention. CORMs offer the promising possibility of a safe and controllable release of CO in low amounts triggered by light, ligands, enzymes, etc. For the targeting of specific tissues or diseases and to prevent possible side effects from metals and other residues after CO release, these CORMs are attached to biocompatible systems, like peptides, polymers, nanoparticles, dendrimers, protein cages, non-wovens, tablets, and metal–organic frameworks. We discuss in this review the known CORM carrier conjugates, in short CORM conjugates, with covalently-bound or incorporated CORMs for medicinal and therapeutic applications. Most conjugates are nontoxic, show increasing half-lives of CO release, and make use of the EPR-effect, but still show problems because of a continuous background of CO release and the absence of an on/off-switch for the CO release.

Graphical abstract: CO-releasing molecule (CORM) conjugate systems

Article information

Article type
Perspective
Submitted
09 Sep 2016
Accepted
17 Oct 2016
First published
18 Oct 2016
This article is Open Access
Creative Commons BY-NC license

Dalton Trans., 2016,45, 18045-18063

CO-releasing molecule (CORM) conjugate systems

A. C. Kautz, P. C. Kunz and C. Janiak, Dalton Trans., 2016, 45, 18045 DOI: 10.1039/C6DT03515A

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