Jump to main content
Jump to site search

Issue 46, 2016
Previous Article Next Article

“Head-to-head” double-hamburger-like structure of di-ruthenated d(GpG) adducts of mono-functional Ru–arene anticancer complexes

Author affiliations

Abstract

Guanine bases in DNA are targets for some Ru–arene anticancer complexes. We have investigated the structure of the novel di-ruthenated d(GpG) adduct Ru2-GpG (where Ru = {(η6-biphenyl)-Ru(en)}2+ (1′)) in aqueous solution. 2D NMR results indicate that there are two conformers, supported by modeling studies. The major conformer I is a novel double-hamburger-like structure with a “head-to-head” (HH) base arrangement involving hydrophobic interactions between neighboring arene rings, the first example of a HH d(GpG) adduct constructed by weak interactions. Hence there are significant differences compared to Pt-d(GpG) adducts formed by cisplatin. There is no obviously rigid bending for the major conformer I. The minor conformer II of Ru2-GpG has a back-to-back structure, with two ruthenated guanine bases flipped away from each other. 19-23 base-pair oligodeoxyribonucleotides containing central TGGT sequences di-ruthenated by 1 show no directional bending, only slightly distorted di-ruthenated duplexes, consistent with the NMR data for conformer I. The structural differences and similarities of d(GpG) residues which are di-ruthenated or cross-linked by platination are discussed in the context of the biological activity of these metal complexes.

Graphical abstract: “Head-to-head” double-hamburger-like structure of di-ruthenated d(GpG) adducts of mono-functional Ru–arene anticancer complexes

Back to tab navigation

Supplementary files

Publication details

The article was received on 27 Aug 2016, accepted on 31 Oct 2016 and first published on 10 Nov 2016


Article type: Paper
DOI: 10.1039/C6DT03356C
Citation: Dalton Trans., 2016,45, 18676-18688
  •   Request permissions

    “Head-to-head” double-hamburger-like structure of di-ruthenated d(GpG) adducts of mono-functional Ru–arene anticancer complexes

    H. Liu, H. Kostrhunova, A. Habtemariam, Y. Kong, R. J. Deeth, V. Brabec and P. J. Sadler, Dalton Trans., 2016, 45, 18676
    DOI: 10.1039/C6DT03356C

Search articles by author

Spotlight

Advertisements