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Issue 30, 2016
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New [(η5-C5H5)Ru(N–N)(PPh3)][PF6] compounds: colon anticancer activity and GLUT-mediated cellular uptake of carbohydrate-appended complexes

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Abstract

Eight ruthenium(II) compounds of the general formula [(η5-C5H5)Ru(N–N)(PPh3)][PF6] were rationally designed, exhibiting high cytotoxicity against HCT116 human colon cancer cells, with IC50 between 14.56 and 1.56 μM; importantly, compounds 5Ru and 6Ru are the first reported ruthenium glycoconjugates exploiting glucose transporters, widely overexpressed in cancer, for cellular uptake.

Graphical abstract: New [(η5-C5H5)Ru(N–N)(PPh3)][PF6] compounds: colon anticancer activity and GLUT-mediated cellular uptake of carbohydrate-appended complexes

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Publication details

The article was received on 22 Apr 2016, accepted on 12 May 2016 and first published on 12 May 2016


Article type: Communication
DOI: 10.1039/C6DT01571A
Citation: Dalton Trans., 2016,45, 11926-11930
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    New [(η5-C5H5)Ru(N–N)(PPh3)][PF6] compounds: colon anticancer activity and GLUT-mediated cellular uptake of carbohydrate-appended complexes

    P. R. Florindo, D. M. Pereira, P. M. Borralho, P. J. Costa, M. F. M. Piedade, C. M. P. Rodrigues and A. C. Fernandes, Dalton Trans., 2016, 45, 11926
    DOI: 10.1039/C6DT01571A

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