Issue 4, 2016

Cobaltoceniumethynyl gold(i) as an unusual heterodinuclear bioorganometallic fragment to study the biological properties of alkynyl gold complexes

Abstract

A cobaltoceniumethynyl gold(I) complex with a triphenylphosphane ligand triggered efficient cytotoxic effects in cancer cells in contrast to a derivative with two cobaltocenium moieties. The complex effectively inhibited the enzyme thioredoxin reductase (TrxR) suggesting this enzyme as a possible biological target. The cellular uptake of both metal fragments of the active complex was studied by atomic absorption spectroscopy and indicated a high biological stability of the complex.

Graphical abstract: Cobaltoceniumethynyl gold(i) as an unusual heterodinuclear bioorganometallic fragment to study the biological properties of alkynyl gold complexes

Supplementary files

Article information

Article type
Communication
Submitted
08 Dec 2015
Accepted
21 Dec 2015
First published
23 Dec 2015
This article is Open Access
Creative Commons BY-NC license

Dalton Trans., 2016,45, 1345-1348

Author version available

Cobaltoceniumethynyl gold(I) as an unusual heterodinuclear bioorganometallic fragment to study the biological properties of alkynyl gold complexes

S. Vanicek, H. Kopacka, K. Wurst, S. Vergeiner, S. Kankowski, J. Schur, B. Bildstein and I. Ott, Dalton Trans., 2016, 45, 1345 DOI: 10.1039/C5DT04796J

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