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Issue 33, 2016
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Peptide-mediated vectorization of metal complexes: conjugation strategies and biomedical applications

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Abstract

The rich chemical and structural versatility of transition metal complexes provides numerous novel paths to be pursued in the design of molecules that exert particular chemical or physicochemical effects that could operate over specific biological targets. However, the poor cell permeability of metallodrugs represents an important barrier for their therapeutic use. The conjugation between metal complexes and a functional peptide vector can be regarded as a versatile and potential strategy to improve their bioavailability and accumulation inside cells, and the site selectivity of their effect. This perspective lies in reviewing the recent advances in the design of metallopeptide conjugates for biomedical applications. Additionally, we highlight the studies where this approach has been directed towards the incorporation of redox active metal centers into living organisms for modulating the cellular redox balance, as a tool with application in anticancer therapy.

Graphical abstract: Peptide-mediated vectorization of metal complexes: conjugation strategies and biomedical applications

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Publication details

The article was received on 17 Nov 2015, accepted on 31 Mar 2016 and first published on 01 Apr 2016


Article type: Perspective
DOI: 10.1039/C5DT04529K
Author version available: Download Author version (PDF)
Citation: Dalton Trans., 2016,45, 12970-12982
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    Peptide-mediated vectorization of metal complexes: conjugation strategies and biomedical applications

    M. Soler, L. Feliu, M. Planas, X. Ribas and M. Costas, Dalton Trans., 2016, 45, 12970
    DOI: 10.1039/C5DT04529K

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